| 12/11/2024 |
Vahan Martirosian |
Intercellular nanotube-mediated mitochondrial transfer enhances T cell metabolic fitness and antitumor efficacy. Baldwin JG, Heuser-Loy C, Saha T, Schelker RC, Slavkovic-Lukic D, Strieder N, Hernandez-Lopez I, Rana N, Barden M, Mastrogiovanni F, Martín-Santos A, Raimondi A, Brohawn P, Higgs BW, Gebhard C, Kapoor V, Telford WG, Gautam S, Xydia M, Beckhove P, Frischholz S, Schober K, Kontarakis Z, Corn JE, Iannacone M, Inverso D, Rehli M, Fioravanti J, Sengupta S, Gattinoni L. Cell. 2024 Nov 14;187(23):6614-6630.e21. doi: 10.1016/j.cell.2024.08.029. Epub 2024 Sep 13. PMID: 39276774; PMCID: PMC11623344. |
| 11/6/2024 |
Honey Win |
Transient loss of Polycomb components induces an epigenetic cancer fate. Parreno V, Loubiere V, Schuettengruber B, Fritsch L, Rawal CC, Erokhin M, Győrffy B, Normanno D, Di Stefano M, Moreaux J, Butova NL, Chiolo I, Chetverina D, Martinez AM, Cavalli G. Nature. 2024 May;629(8012):688-696. doi: 10.1038/s41586-024-07328-w. Epub 2024 Apr 24. PMID: 38658752; PMCID: PMC11096130. |
| 10/16/2024 |
Berney Peng |
Single-cell analysis reveals context-dependent, cell-level selection of mtDNA. Kotrys AV, Durham TJ, Guo XA, Vantaku VR, Parangi S, Mootha VK. Nature. 2024 May;629(8011):458-466. doi: 10.1038/s41586-024-07332-0. Epub 2024 Apr 24. PMID: 38658765; PMCID: PMC11078733. |
| 9/18/2024 |
Mary Doan |
Lysosomes drive the piecemeal removal of mitochondrial inner membrane. Prashar A, Bussi C, Fearns A, Capurro MI, Gao X, Sesaki H, Gutierrez MG, Jones NL. Nature. 2024 Aug;632(8027):1110-1117. doi: 10.1038/s41586-024-07835-w. Epub 2024 Aug 21. PMID: 39169179. |
| 8/14/2024 |
Thang Nguyen |
Design principles of 3D epigenetic memory systems. Owen JA, Osmanović D, Mirny L. Science. 2023 Nov 17;382(6672):eadg3053. doi: 10.1126/science.adg3053. Epub 2023 Nov 17. PMID: 37972190; PMCID: PMC11075759. |
| 5/15/2024 |
Bowen Wang |
A microwell platform for high-throughput longitudinal phenotyping and selective retrieval of organoids. Sockell A, Wong W, Longwell S, Vu T, Karlsson K, Mokhtari D, Schaepe J, Lo YH, Cornelius V, Kuo C, Van Valen D, Curtis C, Fordyce PM. Cell Systems. 2023 Sep 20;14(9):764-776.e6. doi: 10.1016/j.cels.2023.08.002. PMID: 37734323. |
| 4/10/2024 |
Vahan Martirosian |
Metabolic regulation of species-specific developmental rates. Diaz-Cuadros M, Miettinen TP, Skinner OS, Sheedy D, Díaz-García CM, Gapon S, Hubaud A, Yellen G, Manalis SR, Oldham WM, Pourquié O.Nature. 2023 Jan;613(7944):550-557. doi: 10.1038/s41586-022-05574-4. Epub 2023 Jan 4. Erratum in: Nature. 2023 Apr;616(7956):E4. PMID: 36599986; PMCID: PMC9944513. |
| 3/13/2024 |
Honey Win |
Efficient elimination of MELAS-associated m.3243G mutant mitochondrial DNA by an engineered mitoARCUS nuclease. Shoop WK, Lape J, Trum M, Powell A, Sevigny E, Mischler A, Bacman SR, Fontanesi F, Smith J, Jantz D, Gorsuch CL, Moraes CT. Nature Metabolism. 2023 Dec;5(12):2169-2183. doi: 10.1038/s42255-023-00932-6. Epub 2023 Nov 30. PMID: 38036771; PMCID: PMC10730414. |
| 2/14/2024 |
Berney Peng |
Regulators of mitonuclear balance link mitochondrial metabolism to mtDNA expression. Kramer NJ, Prakash G, Isaac RS, Choquet K, Soto I, Petrova B, Merens HE, Kanarek N, Churchman LS. Nature Cell Biology. 2023 Nov;25(11):1575-1589. doi: 10.1038/s41556-023-01244-3. Epub 2023 Sep 28. PMID: 37770567. |
| 1/24/2024 |
Mary Doan |
Amino acid intake strategies define pluripotent cell states. Todorova PK, Jackson BT, Garg V, Paras KI, Brunner JS, Bridgeman AE, Chen Y, Baksh SC, Yan J, Hadjantonakis AK, Finley LWS. Nature Metabolism. 2024 Jan 3. doi: 10.1038/s42255-023-00940-6. Epub ahead of print. PMID: 38172382. |
| 12/6/2023 |
Amy Vandiver |
Mitochondrial DNA breaks activate an integrated stress response to reestablish homeostasis. Fu Y, Sacco O, DeBitetto E, Kanshin E, Ueberheide B, Sfeir A. Molecular Cell. 2023 Oct 19;83(20):3740-3753.e9. doi: 10.1016/j.molcel.2023.09.026. Epub 2023 Oct 12. PMID: 37832546. |
| 11/15/2023 |
Thang Nguyen |
Live-cell micromanipulation of a genomic locus reveals interphase chromatin mechanics. Keizer VIP, Grosse-Holz S, Woringer M, Zambon L, Aizel K, Bongaerts M, Delille F, Kolar-Znika L, Scolari VF, Hoffmann S, Banigan EJ, Mirny LA, Dahan M, Fachinetti D, Coulon A. Science. 2022 Jul 29;377(6605):489-495. doi: 10.1126/science.abi9810. Epub 2022 Jul 28. PMID: 35901134. |
| 10/18/2023 |
Bowen Wang |
Mechanical engineering of hair follicle regeneration by in situ bioprinting. Chen H, Zhang Y, Zhou D, Ma X, Yang S, Xu T. Biomater Advances. 2022 Nov;142:213127. doi: 10.1016/j.bioadv.2022.213127. Epub 2022 Sep 26. PMID: 36244245. |
| 8/23/2023 |
Vahan Martirosian |
GAP43-dependent mitochondria transfer from astrocytes enhances glioblastoma tumorigenicity. Watson DC, Bayik D, Storevik S, Moreino SS, Sprowls SA, Han J, Augustsson MT, Lauko A, Sravya P, Røsland GV, Troike K, Tronstad KJ, Wang S, Sarnow K, Kay K, Lunavat TR, Silver DJ, Dayal S, Joseph JV, Mulkearns-Hubert E, Ystaas LAR, Deshpande G, Guyon J, Zhou Y, Magaut CR, Seder J, Neises L, Williford SE, Meiser J, Scott AJ, Sajjakulnukit P, Mears JA, Bjerkvig R, Chakraborty A, Daubon T, Cheng F, Lyssiotis CA, Wahl DR, Hjelmeland AB, Hossain JA, Miletic H, Lathia JD. Nat Cancer. 2023 May;4(5):648-664. doi: 10.1038/s43018-023-00556-5. Epub 2023 May 11. PMID: 37169842; PMCID: PMC10212766. |
| 6/21/2023 |
Honey Win |
Lysine catabolism reprograms tumour immunity through histone crotonylation. Yuan H, Wu X, Wu Q, Chatoff A, Megill E, Gao J, Huang T, Duan T, Yang K, Jin C, Yuan F, Wang S, Zhao L, Zinn PO, Abdullah KG, Zhao Y, Snyder NW, Rich JN. Nature. 2023 May;617(7962):818-826. doi: 10.1038/s41586-023-06061-0. Epub 2023 May 17. PMID: 37198486. |
| 5/24/2023 |
Mary Doan |
Acetylcarnitine shuttling links mitochondrial metabolism to histone acetylation and lipogenesis. Izzo LT, Trefely S, Demetriadou C, Drummond JM, Mizukami T, Kuprasertkul N, Farria AT, Nguyen PTT, Murali N, Reich L, Kantner DS, Shaffer J, Affronti H, Carrer A, Andrews A, Capell BC, Snyder NW, Wellen KE. Science Advances. 2023 May 3;9(18):eadf0115. doi: 10.1126/sciadv.adf0115. Epub 2023 May 3. PMID: 37134161; PMCID: PMC10156126. |
| 4/19/2023 |
Berney Peng |
Loss of epigenetic information as a cause of mammalian aging. Yang JH, Hayano M, Griffin PT, Amorim JA, Bonkowski MS, Apostolides JK, Salfati EL, Blanchette M, Munding EM, Bhakta M, Chew YC, Guo W, Yang X, Maybury-Lewis S, Tian X, Ross JM, Coppotelli G, Meer MV, Rogers-Hammond R, Vera DL, Lu YR, Pippin JW, Creswell ML, Dou Z, Xu C, Mitchell SJ, Das A, O'Connell BL, Thakur S, Kane AE, Su Q, Mohri Y, Nishimura EK, Schaevitz L, Garg N, Balta AM, Rego MA, Gregory-Ksander M, Jakobs TC, Zhong L, Wakimoto H, El Andari J, Grimm D, Mostoslavsky R, Wagers AJ, Tsubota K, Bonasera SJ, Palmeira CM, Seidman JG, Seidman CE, Wolf NS, Kreiling JA, Sedivy JM, Murphy GF, Green RE, Garcia BA, Berger SL, Oberdoerffer P, Shankland SJ, Gladyshev VN, Ksander BR, Pfenning AR, Rajman LA, Sinclair DA. Cell. 2023 Jan 19;186(2):305-326.e27. doi: 10.1016/j.cell.2022.12.027. Epub 2023 Jan 12. PMID: 36638792. |
| 3/22/2023 |
Amy Vandiver |
Multiomics reveals glutathione metabolism as a driver of bimodality during stem cell aging. Benjamin DI, Brett JO, Both P, Benjamin JS, Ishak HL, Kang J, Kim S, Chung M, Arjona M, Nutter CW, Tan JH, Krishnan AK, Dulay H, Louie SM, de Morree A, Nomura DK, Rando TA. Cell Metabolism. 2023 Mar 7;35(3):472-486.e6. doi: 10.1016/j.cmet.2023.02.001. Epub 2023 Feb 27. PMID: 36854304; PMCID: PMC10015599. |
| 3/1/2023 |
Thang Nguyen |
Extracellular fluid viscosity enhances cell migration and cancer dissemination. Bera K, Kiepas A, Godet I, Li Y, Mehta P, Ifemembi B, Paul CD, Sen A, Serra SA, Stoletov K, Tao J, Shatkin G, Lee SJ, Zhang Y, Boen A, Mistriotis P, Gilkes DM, Lewis JD, Fan CM, Feinberg AP, Valverde MA, Sun SX, Konstantopoulos K. Nature. 2022 Nov; 611(7935):365-373. doi: 10.1038/s41586-022-05394-6. Epub 2022 Nov 2. PMID: 36323783; PMCID: PMC9646524. |
| 1/11/2023 |
Bowen Wang |
Microplankton life histories revealed by holographic microscopy and deep learning. Bachimanchi H, Midtvedt B, Midtvedt D, Selander E, Volpe G. ELife. 2022 Nov 1;11:e79760. doi: 10.7554/eLife.79760. PMID: 36317499; PMCID: PMC9625084. |
| 11/9/2022 |
Amy Yu |
Dietary lipids inhibit mitochondria transfer to macrophages to divert adipocyte-derived mitochondria into the blood. Borcherding N, Jia W, Giwa R, Field RL, Moley JR, Kopecky BJ, Chan MM, Yang BQ, Sabio JM, Walker EC, Osorio O, Bredemeyer AL, Pietka T, Alexander-Brett J, Morley SC, Artyomov MN, Abumrad NA, Schilling J, Lavine K, Crewe C, Brestoff JR. Cell Metab. 2022 Oct 4;34(10):1499-1513.e8. doi: 10.1016/j.cmet.2022.08.010. Epub 2022 Sep 6. PMID: 36070756; PMCID: PMC9547954. |
| 9/28/2022 |
Mary Doan |
Sensitisation of cancer cells to radiotherapy by serine and glycine starvation. Falcone M, Uribe AH, Papalazarou V, Newman AC, Athineos D, Stevenson K, Sauvé CG, Gao Y, Kim JK, Del Latto M, Kierstead M, Wu C, Smith JJ, Romesser PB, Chalmers AJ, Blyth K, Maddocks ODK Br J Cancer. 2022 Sep 17. doi: 10.1038/s41416-022-01965-6. Epub ahead of print. PMID: 36115879. |
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Berney Peng |
Brown-fat-mediated tumour suppression by cold-altered global metabolism. Seki T, Yang Y, Sun X, Lim S, Xie S, Guo Z, Xiong W, Kuroda M, Sakaue H, Hosaka K, Jing X, Yoshihara M, Qu L, Li X, Chen Y, Cao Y. Nature. 2022 Aug;608(7922):421-428. doi: 10.1038/s41586-022-05030-3. Epub 2022 Aug 3. PMID: 35922508; PMCID: PMC9365697. |
| 7/13/2022 |
Thang Nguyen |
Cancer cells use self-inflicted DNA breaks to evade growth limits imposed by genotoxic stress. Larsen BD, Benada J, Yung PYK, Bell RAV, Pappas G, Urban V, Ahlskog JK, Kuo TT, Janscak P, Megeney LA, Elsässer SJ, Bartek J, Sørensen CS. Science. 22022 Apr 29;376(6592):476-483. doi: 10.1126/science.abi6378. Epub 2022 Apr 28. PMID: 35482866. |
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Amy Vandiver |
Heteroplasmy of Wild-Type Mitochondrial DNA Variants in Mice Causes Metabolic Heart Disease With Pulmonary Hypertension and Frailty. Lechuga-Vieco AV, Latorre-Pellicer A, Calvo E, Torroja C, Pellico J, Acín-Pérez R, García-Gil ML, Santos A, Bagwan N, Bonzon-Kulichenko E, Magni R, Benito M, Justo-Méndez R, Simon AK, Sánchez-Cabo F, Vázquez J, Ruíz-Cabello J, Enríquez JA. Circulation. 2022 Apr 5;145(14):1084-1101. doi: 10.1161/CIRCULATIONAHA.121.056286. Epub 2022 Mar 3. PMID: 35236094; PMCID: PMC8969846. |
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Bowen Wang |
Transgenic Aedes aegypti Mosquitoes Transfer Genes into a Natural Population. Evans BR, Kotsakiozi P, Costa-da-Silva AL, Ioshino RS, Garziera L, Pedrosa MC, Malavasi A, Virginio JF, Capurro ML, Powell JR. Scientific Reports. 2019 Sep 10;9(1):13047. doi: 10.1038/s41598-019-49660-6. PMID: 31506595; PMCID: PMC6736937. Editorial Expression of Concern: Link |
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Amy Yu |
Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer. Raghavan S, Winter PS, Navia AW, Williams HL, DenAdel A, Lowder KE, Galvez-Reyes J, Kalekar RL, Mulugeta N, Kapner KS, Raghavan MS, Borah AA, Liu N, Väyrynen SA, Costa AD, Ng RWS, Wang J, Hill EK, Ragon DY, Brais LK, Jaeger AM, Spurr LF, Li YY, Cherniack AD, Booker MA, Cohen EF, Tolstorukov MY, Wakiro I, Rotem A, Johnson BE, McFarland JM, Sicinska ET, Jacks TE, Sullivan RJ, Shapiro GI, Clancy TE, Perez K, Rubinson DA, Ng K, Cleary JM, Crawford L, Manalis SR, Nowak JA, Wolpin BM, Hahn WC, Aguirre AJ, Shalek AK. Cell. 2021 Dec 9;184(25):6119-6137.e26. doi: 10.1016/j.cell.2021.11.017. PMID: 34890551; PMCID: PMC8822455. |
| 2/23/2022 |
Mary Doan |
Mitochondria shed their outer membrane in response to infection-induced stress. Li X, Straub J, Medeiros TC, Mehra C, den Brave F, Peker E, Atanassov I, Stillger K, Michaelis JB, Burbridge E, Adrain C, Münch C, Riemer J, Becker T, Pernas LF. Science. 2022 Jan 14;375(6577):eabi4343. doi: 10.1126/science.abi4343. Epub 2022 Jan 14. PMID: 35025629. |
| 1/12/2022 |
Berney Peng |
Mitochondrial DNA heteroplasmy is modulated during oocyte development propagating mutation transmission. Zhang H, Esposito M, Pezet MG, Aryaman J, Wei W, Klimm F, Calabrese C, Burr SP, Macabelli CH, Viscomi C, Saitou M, Chiaratti MR, Stewart JB, Jones N, Chinnery PF. Science Advances. 2021 Dec 10;7(50):eabi5657. doi: 10.1126/sciadv.abi5657. Epub 2021 Dec 8. PMID: 34878831; PMCID: PMC8654302. |
| 12/1/2021 |
Thang Nguyen |
Stem cells expand potency and alter tissue fitness by accumulating diverse epigenetic memories. Gonzales KAU, Polak L, Matos I, Tierney MT, Gola A, Wong E, Infarinato NR, Nikolova M, Luo S, Liu S, Novak JSS, Lay K, Pasolli HA, Fuchs E. Science. 2021 Nov 26;374(6571):eabh2444. doi: 10.1126/science.abh2444. Epub 2021 Nov 26. PMID: 34822296. |
| 10/13/2021 |
Amy Vandiver |
Chromatin remodeling due to degradation of citrate carrier impairs osteogenesis of aged mesenchymal stem cells. Pouikli, A., Parekh, S., Maleszewska, M., Nikopoulou C., Baghdadi M., Tripodi I., Folz-Donahue K., Hinze Y., Mesaros A., Hoey D., Giavalisco P., Dowell R., Partridge L., and Tessarz P. Nat Aging. 1, 810–825 (2021). https://doi.org/10.1038/s43587-021-00105-8 |
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Alejandro Torres |
Human brain organoids assemble functionally integrated bilateral optic vesicles. Gabriel E, Albanna W, Pasquini G, Ramani A, Josipovic N, Mariappan A, Schinzel F, Karch CM, Bao G, Gottardo M, Suren AA, Hescheler J, Nagel-Wolfrum K, Persico V, Rizzoli SO, Altmüller J, Riparbelli MG, Callaini G, Goureau O, Papantonis A, Busskamp V, Schneider T, Gopalakrishnan J. Cell Stem Cell. 2021 Aug 12:S1934-5909(21)00295-2. doi: 10.1016/j.stem.2021.07.010. Epub ahead of print. PMID: 34407456. |
| 8/11/2021 |
Bowen Wang |
A seismically induced onshore surge deposit at the KPg boundary, North Dakota. DePalma RA, Smit J, Burnham DA, Kuiper K, Manning PL, Oleinik A, Larson P, Maurrasse FJ, Vellekoop J, Richards MA, Gurche L, Alvarez W. PNAS 2019 April; 116 (17) 8190-8199; DOI: 10.1073/pnas.181740718. |
| 7/7/2021 |
Alex Sercel |
Glucose metabolism links astroglial mitochondria to cannabinoid effects. Jimenez-Blasco, D., Busquets-Garcia, A., Hebert-Chatelain, E. et al. Nature 2020 July 8; 583, 603–608. |
| 6/9/2021 |
Amy Yu |
Mitocytosis, a migrasome-mediated mitochondrial quality-control process. Jiao H, Jiang D, Hu X, Du W, Ji L, Yang Y, Li X, Sho T, Wang X, Li Y, Wu Y, Wei Y, Hu X, Li Yu L Cell 2021 May 27; 184(11):2896-2910.e13. doi: 10.1016/j.cell.2021.04.027. |
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Rujuta Sathe |
Membrane Tension Gates ERK-Mediated Regulation of Pluripotent Cell Fate. De Belly H, Stubb A, Yanagida A, Labouesse C, Jones PH, Paluch EK, Chalut KJ, Cell Stem Cell 2021 2021 Feb 4; 28(2):273-284.e6. |
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Vivian Lu |
CRISPR screens in physiologic medium reveal conditionally essential genes in human cells. Rossiter NJ, Huggler KS, Adelmann CH, Keys HR, Soens RW, Sabatini DM, Cantor JR, Cell Metabolism 2021 June 1; 33, pages 1-16 |
| 2/24/2021 |
Berney Peng |
A bacterial cytidine deaminase toxin enables CRISPR-free mitochondrial base editing. Mok BY, de Moraes MH, Zeng J, Bosch DE, Kotrys AV, Raguram A, Hsu F, Radey MC, Peterson SB, Mootha VK, Mougous JD, Liu DR Nature 2020 July 8; 583, pages 631–637(2020) |
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Amy Vandiver |
Reprogramming to recover youthful epigenetic information and restore vision. Lu Y, Brommer B, Tian X, Krishnan A, Meer M, Wang C, Vera DL, Zeng Q, Yu D, Bonkowski MS, Yang J, Zhou S, Hoffmann EM, Karg MM, Schultz MB, Kane AE, Davidsohn N, Korobkina E, Chwalek K, Rajman LA, Church GM, Hochedlinger K, Gladyshev VN, Horvath S, Levine ME, Gregory-Ksander MS, Ksander BR, He Z, Sinclair DA Nature 2020 December; 588, pages 124–129 |
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Thang Nguyen |
Active particles induce large shape deformations in giant lipid vesicles. Vutukuri HR, Hoore M, Abaurrea-Velasco C, van Buren L, Dutto A, Auth T, Fedosov DA, Gompper G, Vermant J Nature 2020 October; 586, pages 52-56 |
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Alejandro Torres |
Cancer SLC43A2 alters T cell methionine metabolism and histone methylation. Bian Y, Li W, Kremer DM, Sajjakulnukit P, Li S, Crespo J, Nwosu ZC, Zhang L, Czerwonka A, Pawłowska A, Xia H, Li J, Liao P, Yu J, Vatan L, Szeliga W, Wei S, Grove S, Liu JR, McLean K, Cieslik M, Chinnaiyan AM, Zgodziński W, Wallner G, Wertel I, Okła K, Kryczek I, Lyssiotis CA & Zou W. Nature 2020 September 2; 585, pages277–282 |
| 9/23/2020 |
Diane Kim |
Unraveling why we sleep: Quantitative analysis reveals abrupt transition from neural reorganization to repair in early development. Cao J, Herman AB, West GB, Poe G, Savage VM. Science Advances 2020 September 18; Vol. 6, no. 38, eaba0398 |
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Nicholas Aguirre |
Glucose Metabolism Drives Histone Acetylation Landscape Transitions that Dictate Muscle Stem Cell Function. Yucel N, Wang YX, Mai T, Porpiglia E, Lund PJ, Markov G, Garcia BA, Bendall SC, Angelo M, Blau HM. Cell Reports 2019 June 25; 27(13):3939-3955.e6. doi: 10.1016/j.celrep.2019.05.092. |
| 8/6/2020 |
Bowen Wang |
Three-dimensional single-cell imaging for the analysis of RNA and protein expression in intact tumour biopsies. Tanaka N, Kanatani S, Kaczynska D, Fukumoto K, Louhivuori L, Mizutani T, Kopper O, Kronqvist P, Robertson S, Lindh C, Kis L, Pronk R, Niwa N, Matsumoto K, Oya M, Miyakawa A, Falk A, Hartman J, Sahlgren C, Clevers H, Uhlén P. Nature Biomedical Engineering 2020 June 29; 0.1038/s41551-020-0576-z |
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Alexander Sercel |
Human Hair Graying is Naturally Reversible and Linked to Stress. Rosenberg A, Rausser S, Ren J, Mosharov E, Sturm G, Ogden RT, Patel P, Soni RK, Lacefield C, Paus R, Picard M. BioRXIV 2020 May 19; 10.1101/2020.05.18.101964 |
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Amy Yu |
Mitochondrial Phosphatase PGAM5 Modulates Cellular Senescence by Regulating Mitochondrial Dynamics. Yu B, Ma J, Li J, Wang D, Wang Z, Wang S. Nature Communications 2020 May 21; 11(1):2549 |
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Vivian Lu |
Sequencing metabolically labeled transcripts in single cells reveals mRNA turnover strategies. Battich N, Beumer J, de Barbanson B, Krenning L, Baron CS, Tanenbaum ME, Clevers H, van Oudenaarden A. Science 2020 Mar 6; 367(6482):1151-1156 |
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Thang Nguyen |
The Quantitative-Phase Dynamics of Apoptosis and Lytic Cell Death. Vicar T, Raudenska M, Gumulec J, Balvan J. Scientific Reports 2020 Jan 31; 10(1):1566 |
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Alex Patananan |
Regulation of Mother-to-Offspring Transmission of mtDNA Heteroplasmy. Latorre-Pellicer A, Lechuga-Vieco AV, Johnston IG, Hämäläinen RH, Pellico J, Justo-Méndez R, Fernández-Toro JM, Clavería C, Guaras A, Sierra R, Llop J, Torres M5, Criado LM, Suomalainen A, Jones NS, Ruíz-Cabello J, Enríquez JA. Cell Metabolism 2019 Dec 3; 30(6):1120-1130 |
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Bowen Wang |
A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity. Sachs N, de Ligt J, Kopper O, Gogola E, Bounova G, Weeber F, Balgobind AV, Wind K, Gracanin A, Begthel H, Korving J, van Boxtel R, Duarte AA, Lelieveld D, van Hoeck A, Ernst RF, Blokzijl F, Nijman IJ, Hoogstraat M, van de Ven M, Egan DA, Zinzalla V, Moll J, Boj SF, Voest EE, Wessels L, van Diest PJ, Rottenberg S, Vries RGJ, Cuppen E, Clevers H. Cell 2018 Jan 11; 172(1-2):373-386 |
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Nick Aguirre |
NURR1 activation in skeletal muscle controls systemic energy homeostasis. Amoasii L, Sanchez-Ortiz E, Fujikawa T, Elmquist JK, Bassel-Duby R, Olson EN.PNAS 4 June 2019; 116(23):11299-11308. |
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Diane Kim |
Deep Learning in Label-free Cell Classification. Chen CL, Mahjoubfar A, Tai LC, Blaby IK, Huang A, Niazi KR, Jalali B.Scientific Reports 15 March 2016; 6:21471. |
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Amy Yu |
Mitohormesis Primes Tumor Invasion and Metastasis. Kenny TC, Craig AJ, Villanueva A, Germain D.Cell Reports.21 May 2019; 27(8):2292-2303. |
| 2/21/2019 |
Jason Hong |
Viscous control of cellular respiration by membrane lipid composition. Budin I, de Rond T, Chen Y, Chan LJG, Petzold CJ, Keasling JD Science. 7 December 2018; 362(6419):1186-1189. |
| 11/1/2018 |
Thang Nguyen |
Tissue stiffening coordinates morphogenesis by triggering collective cell migration in vivo. Barriga EH, Franze K, Charras G, Mayor R. Nature. 22 February 2018; 554(7693):523-527. |
| 8/30/2018 |
Fasih Ahsan |
Immune-centric network of cytokines and cells in disease context identified by computational mining of PubMed. Kveler K, Starosvetsky E, Ziv-Kenet A, Kalugny Y, Gorelik Y, Shalev-Malul G, Aizenbud-Reshef N, Dubovik T, Briller M, Campbell J, Rieckmann JC, Asbeh N, Rimar D, Meissner F, Wiser J, Shen-Orr SS. Nature Biotechnology. August 2018; 36(7):651-659. |
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Alexander Patananan |
Molecular and functional resemblance of differentiated cells derived from isogenic human iPSCs and SCNT-derived ESCs. Zhao M, Chen H, Liu Q, Shao N, Sayed N, Wo H, Zhang J, Ong S, Liu C, Kim Y, Yang H, Chour T, Ma H, Gutierrez N, Karakikes I, Mitalipov S, Snyder M, and Wu J. PNAS. 26 December 2017; 114(52): E11111-E11120. |
| 7/5/2018 |
Lynnea Waters |
p53 inhibits CRISPR-Cas9 engineering in human pluripotent stem cells. Ihry RJ, Worringer KA, Salick MR, Frias E, Ho D, Theriault K, Kommineni S, Chen J, Sondey M, Ye C, Randhawa R, Kulkarni T, Yang Z, McAllister G, Russ C, Reece-Hoyes J, Forrester W, Hoffman GR, Dolmetsch R, Kaykas A Nature Medicine. 11 June 2018; In Press |
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Vivian Lu |
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Mitochondrial Pyruvate Import Promotes Long-Term Survival of Antibody-Secreting Plasma Cells. Lam WY, Becker AM, Kennerly KM, Wong R, Curtis JD, Llufrio EM, McCommis KS, Fahrmann J, Pizzato HA, Nunley RM, Lee J, Wolfgang MJ, Patti GJ, Finck BN, Pearce EL, Bhattacharya D. Immunity. 19 July 2016; 45(1): 60-73. |
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Parkinson's Disease-Related Proteins PINK1 and Parkin Repress Mitochondrial Antigen Presentation. Matheoud D, Sugiura A, Bellemare-Pelletier A, Laplante A, Rondeau C, Chemali M, Fazel A, Bergeron JJ, Trudeau LE, Burelle Y, Gagnon E, McBride HM, Desjardins M. Cell. 14 July 2016; 166(2): 314-327. |
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BRAF Mutants Evade ERK-Dependent Feedback by Different Mechanisms that Determine Their Sensitivity to Pharmacologic Inhibition. Yao Z, Torres N, Tao A, Gao Y, Luo L, Li Q, de Stanchina E, Abdel-Wahab O, Solit D, Poulikakos P, Rosen N. Cancer Cell. 14 September 2015; 28: 370-383 |
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Metabolic Rescue in Pluripotent Cells From Patients with mtDNA Disease. Ma H, Folmes C, Wu J, Morey R, Mora-Castilla S, Ocampo A, Ma L, Poulton J, Wang X, Ahmed R, Kang E, Lee Y, Hayama T, Li Y, Van Dyken C, Gutierrez N, Tippner-Hedges R, Koski1 A, Mitalipov N, Amato P, Wolf D,Huang T, Terzic A, Laurent L, Belmonte J, Mitalipov S. Nature. 15 July 2015; 14546: 1-5 |
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Compartmentalized AMPK Signaling Illuminated by Genetically Encoded Molecular Sensors and Actuators. Miyamoto T, Rho E, Sample V, Akano H, Magari M, Ueno T, Gorshkov K, Chen M, Tokumitsu H, Zhang J, Inoue T. Cell Reports. 28 April 2015; 11: 657-670 |
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Mitochondrial DNA Stress Primes the Antiviral Innate Immune Response. West A, Khoury-Hanold W, Staron M, Tal M, Pineda C, Lang S, Bestwick M, Duguay B, Raimundo N, MacDuff D, Kaech S, Smiley J, Means R, Iwasaki A, Shadel G. Nature. 23 April 2015; 520: 553-557 |
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Glycolysis-Mediated Changes in Acetyl-CoA and Histone Acetylation Control the Early Differentiation of Embryonic Stem Cells. Moussaieff A, Rouleau M, Kitsberg D, Cohen M, Levy G, Barasch D, Nemirovski A, Shen-Orr S, Laevsky I, Amit M, Bomze D, Elena-Herrmann B, Scherf T, Nissim-Rafinia M, Kempa S, Itskovitz-Eldor J, Meshorer E, Aberdam D, Nahmias Y Cell Metabolism. 3 March 2015; 21: 392-402 |
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MicroRNA Directly Enhances Mitochondrial Translation during Muscle Differentiation. Zhang X, Zuo X, Yang B, Li Z, Xue Y, Zhou Y, Huang J, Zhao X, Zhou J, Yan Y, Zhang H, Guo P, Sun H, Guo L, Zhang Y, Fu X-D. Cell. 31 July 2014; 158: 607-619 |
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Oncogenic BRAF induces chronic ER stress condition resulting in increased basal autophagy and apoptotic resistance of cutaneous melanoma. Corazzari M, Rapino F, Ciccosanti F, Giglio P, Antonioli M, Conti B, Fimia GM, Lovat PE, Piacentini M Cell Death and Differentiation. 7 November 2014; 1-13 |
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Arginine Methylation of CRTC2 Is Critical in the Transcriptional Control of Hepatic Glucose Metabolism. Han H-S, Jung C-Y, Yoon Y-S, Choi S, Choi D, Kang G, Park K-G, Kim S-T, Koo S-H. Science Signaling. 25 February 2014; 7(314) ra19: 1-9 |
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An AMPK-Independent Signaling Pathway Downstream of the LKB1 Tumor Suppressor Controls Snail1 and Metastatic Potential. Goodwin J, Svensson R, Lou H, Winslow M, Turk B, Shaw R Molecular Cell. 7 August 2014; 55: 436-450 |
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Polar Body Genome Transfer for Preventing the Transmission of Inherited Mitochondrial Diseases. Wang T, Sha H, Ji D, Zhang H, Chen D, Cao Y, Zhu J. Cell. 19 June 2014; 157: 1591-1604 |
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A Bicistronic MAVS Transcript Highlights a Class of Truncated Variants in Antiviral Immunity. Brubaker S, Gauthier A, Mills E, Ingolia N, Kagan J. Cell. 13 February 2014; 156: 800-811 |
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The Mitochondrial RNA-Binding Protein GRSF1 Localizes to RNA Granules and Is Required for Posttranscriptional Mitochondrial Gene Expression. Antonicka H, Sasarman F, Nishimura T, Paupe V, Shoubridge E. Cell Metabolism. 5 March 2013; 17: 386-398 |
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Dynamics Extracted from Fixed Cells Reveal Feedback Linking Cell Growth to Cell Cycle. Kafri R, Levy J, Ginzberg M, Oh S, Lahav G, Kirschner M. Nature. 28 February 2014; 494: 480-483 |
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Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging. Gomes A, Price N, Ling A, Moslehi J, Montgomery M, Rajman L, White J, Teodoro J, Wrann C, Hubbard B, Mercken E, Palmeira C, de Cabo R, Rolo A, Turner N, Bell E, Sinclair D. Cell. 19 December 2013; 155: 1624-1638 |
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Germinal Center B Cells Govern Their Own Fate via Antibody Feedback. Zhang Y, Meyer-Hermann M, George L, Figge M, Khan M, Goodall M, Young S, Reynolds A, Falciani F, Waisman A, Notley C, Ehrenstein M, Kosco-Vilbois M, Toellner K-M. The Journal of Experimental Medicine. 18 Feb 2013; 210(3): 457-464 |
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c-Myc Is a Universal Amplifier of Expressed Genes in Lymphocytes and Embryonic Stem Cells. Nie Z, Hu G, Wei G, Cui K, Yamane A, Resch W, Wang R, Green D, Tessarollo L, Casellas R, Zhao K, Levens D. Cell. 28 Sep 2012; 151: 68-79 |
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Molecular Pathway and Cell State Responsible for Dissociation-Induced Apoptosis in Human Pluripotent Stem Cells.Ohgushi M, Matsumura M, Eiraku M, Murakami K, Aramaki T, Nishiyama A, Muguruma K, Nakano T, Suga H, Ueno M, Ishizaki T, Suemori H, Narumiya S, Niwa H, Sasai Y, Cell Stem Cell. 6 Aug 2010;7(2):225-239 |
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ATMIN Is Required for Maintenance of Genomic Stability and Suppression of B Cell Lymphoma. Loizou JI, Sancho R, Kanu N, Bolland DJ, Yang F, Rada C, Corcoran AE, Behrens A. Cancer Cell. 17 May 2011; 19(5):587-600 |
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Lkb1 Regulates Cell Cycle and Energy Metabolism in Haematopoietic Sem Cells. Nakada D, Saunders TL, Morrison SJ. Nature. 2010 Dec 10; 468:653-658 |
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Essential Regulation of Cell Bioenergetics by Constitutive InsP3 Receptor Ca2+ Transfer to Mitochondria. Cárdenas C, Miller RA, Smith I, Bui T, Molgó J, Müller M, Vais H, Cheung K-H, Yang J, Parker I, Thompson CB, Birnbaum MJ, Hallows KR, Foskett JK. Cell. 2010 July 23; 142(2): 270-283 |
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Intracellular Fluid Flow in Rapidly Moving Cells. Keren K, Yam PT, Kinkhabwala A, Mogilner A, Theriot JA. Nature Cell Biology. 2009 Sept 20; 11: 1219 – 1224 |
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Hsiao-Wen |
Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase. Cancer Cell. 7:77-85, 2005 |
| 9/15/2005 |
Mike |
PUMA Couples the Nuclear and Cytoplasmic Proapoptotic Function of p53. Science. 309:1732-1735, 2005 |
| 9/1/2005 |
Matt |
Evasion of the p53 tumour surveillance network by tumour-derived MYC mutants. Nature. 436:807-811, 2005 |
| 8/18/2005 |
Cynthia |
Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis. Nature. 436:725-730, 2005 |
| 8/4/2005 |
Ali |
Identification of bronchioalveolar stem cells in normal lung and lung cancer. Cell. 121:823-835, 2005 |
| 7/21/2005 |
Rhine |
A genetic screen for candidate tumor suppressors identifies REST. Cell. 121:837-848, 2005 |
| 7/7/2005 |
Sarah |
The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair. Nature Cell Biology. 7:195-201, 2005 |
| 6/23/2005 |
Dave |
Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor pathway. Nature Medicine. 11:71-76, 2005 |
| 6/2/2005 |
Daphne |
Observation of nuclear fusion driven by a pyroelectric crystal. Nature. 434:1115-1117, 2005 |
| 5/19/2005 |
Mike |
Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis. Cell. 121:179-193, 2005 |
| 5/5/2005 |
Matt |
hDOT1L links histone methylation to leukemogenesis. Cell. 121:167-178, 2005 |
| 4/21/2005 |
Sam |
Control of cell proliferation and apoptosis by mob as tumor suppressor, mats. Cell. 120:675-685, 2005 |
| 4/14/2005 |
Hsiao-Wen |
Positive contribution of pathogenic mutations in the mitochondrial genome to the promotion of cancer by prevention from apoptosis. Cancer Research. 65:1655-1663, 2005 |
| 3/3/2005 |
Cynthia |
Oncogene, adv online pub |
| 2/17/2005 |
Ali |
Specific peptide interference reveals BCL6 transcriptional and oncogenic mechanisms in B-cell lymphoma cells. Nature Med. 10:1329-1355, 2004 |
| 2/3/2005 |
Rhine |
Role of the proto-oncogene Pokemon in cellular transformation and ARF repression. Nature. 433:278-285, 2005 |
| 1/20/2005 |
Sarah |
Genome-wide survey of protein kinases required for cell cycle progression. Nature. 432:980-987, 2004 |
| 1/6/2005 |
Dave |
Gastric cancer originating from bone marrow-derived cells. Science. 306: 1568-1571, 2004 |
| 12/9/2004 |
Mike |
The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells. Nature. 432:635-639, 2004 |
| 11/11/2004 |
Daphne |
Efficient active transport of gene nanocarriers to the cell nucleus. PNAS. 100:3878-3882, 2004 |
| 10/28/2004 |
Mike |
MTA3 and the Mi-2/NuRD complex regulate cell fate during B lymphocyte differentiation. Cell. 119:75-86, 2004 |
| 10/14/2004 |
Mike |
Inhibition of Akt kinase activity by a peptide spanning the betaA strand of the proto-oncogene TCL1. J Biol Chem. 2004 Dec 17;279(51):53407-18 |
| 9/23/2004 |
Matt |
Human PAD4 regulates histone arginine methylation levels via demethylimination. Science. 2004 Oct 8;306(5694):279-83 |
| 9/2/2004 |
Ksenia |
Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy. Nature. 2004 428:332-337 |
| 8/19/2004 |
Sam |
Disruption of mitochondrial function during apoptosis is mediated by caspase cleavage of the p75 subunit of complex I of the electron transport chain. Cell. 117:773-786, 2004 |
| 8/5/2004 |
Hsaio-Wen |
Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex. Nat Cell Biol. 2004 May;6(5):386-8 |
| 7/22/2004 |
Rhine |
Separate domains of AID are required for somatic hypermutation and class-switch recombination. Nat Immunol. 2004 Jul;5(7):707-12 |
| 7/8/2004 |
Francesca |
Transcriptional gene silencing promotes DNA hypermethylation through a sequential change in chromatin modifications in cancer cells. Cancer Research. 64:3871-3877, 2004 |
