February 02, 2021 DAILY BRUIN: UCLA researchers develop new technology allowing for greater mitochondrial research UCLA researchers can transfer mitochondria from one cell into another reprogrammable cell at a high rate using a newly developed technology called MitoPunch, according to UCLA research published in late December.
December 29, 2020 UCLA Scientists Develop High-Throughput Mitochondria Transfer Device Scientists in the Teitell Lab, from the UCLA Jonsson Comprehensive Cancer Center, have developed a simple, high-throughput method for transferring isolated mitochondria and their associated mitochondrial DNA into mammalian cells. This approach enables researchers to tailor a key genetic component of cells, to study and potentially treat debilitating diseases such as cancer, diabetes and metabolic disorders. They published their findings in Cell Reports on December 29, 2020, in a paper titled, Pressure-Driven Mitochondrial Transfer Pipeline Generates Mammalian Cells of Desired Genetic Combinations and Fates.
October 16, 2018 Teitell Lab Publications Featured in “Cell Press Selections Stem Cell Metabolism: Fate Regulation and Disease Modeling” Reprint Compendium Cell Press has chosen two Teitell lab publications for its special reprint edition. These publications include: Metabolism in Pluripotent Stem Cells and Early Mammalian Development (Zhang, et al, Cell Metabolism) and α-Ketoglutarate Accelerates the Initial Differentiation of Primed Human Pluripotent Stem Cells (TeSlaa, et al, Cell Metabolism) published in 2016.
August 08, 2017 Teitell Appointed Director of the UCLA Jonsson Comprehensive Cancer Center Dr. Michael Teitell has been appointed as the Director of the Jonsson Comprehensive Cancer Center and President of the Jonsson Cancer Center Foundation.
July 30, 2016 UCLA Scientists Uncover Metabolic Molecule Accelerating Stem Cell Differentiation University of California, Los Angeles/Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research (BSCRC) – Researchers at the UCLA BSCRC and the Laboratory of Dr. Michael Teitell have discovered that an intermediary metabolic molecule, α-ketoglutarate, is a significant factor in accelerating the differentiation of pluripotent stem cells into specialized cell types. This study, published online in press today in the journal Cell Metabolism, displays a foundation on which future work can be focused on studying how metabolite production promotes stem cell differentiation.
May 10, 2016 UCLA Researchers Use a Nanoblade to Transfer Mitochondria into Living Cells University of California, Los Angeles – In a recent study and review published by Cell Metabolism (23: 785-796, 921-929; 10 May 2016), members of the Teitell Lab in the Department of Pathology and Laboratory Medicine report a landmark proof-of-principle transfer of isolated mitochondria into mammalian cells using the photothermal nanoblade, restoring metabolic network activity in mitochondrial DNA-deficient cells. A highly efficient delivery mechanism for large cargoes into living cells, the nanoblade platform represents a novel methodology for studying mitochondrial disease and can deliver insight into the future of mitochondrial reverse genetics.
January 11, 2016 Nature Methods Highlights Photothermal Nanoblade and BLAST Technologies for Delivering Difficult Cargo into Cells Nature Methods – In an interview for the Technology Feature (Volume 13, No. 1, January 2016, pp 37-40), Drs. Michael Teitell and Eric Pei-Yu Chiou described their recently invented cargo delivery systems. The nanoblade and BLAST (Biophotonic Laser-Assisted Surgery Tool) are novel platforms that can deliver large cargo up to 3 µm in diameter into cells. These technologies are being commercialized in a biotechnology start-up company, NanoCav, to provide these tools to academia and industry.
July 17, 2015 Teitell Comments on Mitalipov lab Nature Study on Mitochondrial Swap in The Scientist Los Angeles – According to a new study published in Nature, a method for correcting diseases caused by mitochondrial DNA mutations has been developed for somatic cells. However, it is uncertain how this therapy can to be used effectively. Dr. Michael Teitell, a professor of pediatrics and pathology at the University of California, Los Angeles, commented on this method and its place in regenerative medicine.
April 08, 2015 UCLA Researchers Develop High-Throughput Delivery System for Placing Large Cargo into Cells Los Angeles – Technology was developed by the laboratories of Dr. Pei-Yu Chiou and Dr. Michael Teitell to deliver large objects, up to 3 microns in diameter, into a wide range of mammalian cells. In a long term collaboration between the Henry Samueli School of Engineering and Applied Science and the David Geffen School of Medicine at UCLA, the Chiou and Teitell groups developed a high-throughput platform that delivers large cargo into 10,000- 100,000 cells per minute. The multi-delivery platform system uses a laser pulse to open a re-sealable hole in the cell membrane to deliver functional nanoparticles, enzymes, antibodies, and live intracellular pathogenic bacteria into cells at a highly efficient rate, well beyond the capabilities for existing technologies in this area.
December 05, 2014 Teitell co-hosts Cell Stem Cell and Cell Metabolism Symposium on Stem Cell Energetics in Berkeley, CA Los Angeles – Drs. Michael Teitell and Emanuelle Passegue (UCSF) are partnering with Nikla Emambokus (Editor in Chief, Cell Metabolism) and Sheila Chari (Reviews Editor, Cell Stem Cell) to co-organize and co-host a scientific symposium on Stem Cell Energetics at the Claremont Hotel & Spa, Berkeley, CA from December 9-11, 2014.
May 21, 2014 Teitell Lab Collaborates on Study of Metabolite that Extends Lifespan in Worms Los Angeles – The Teitell lab collaborated with Dr. Jing Huang of the UCLA Department of Molecular Pharmacology to study the role of metabolites on lifespan extension. Alpha-ketoglutarate, available in some dietary supplements, extends the lifespan in the nematode worm, Caenorhabditis elegans, by interfering with cellular energy production and mimicking the effects of severe calorie restriction. The results, published in Nature, suggest that α-ketoglutarate might provide a way to increase longevity one day.
May 13, 2014 Teitell Lab Collaborates on Study Linking WNT Signaling and Metabolism to Colon Cancer Los Angeles – It has been known for some time that Wnt signaling has been involved in the development of many cancers, including colon cancer. However, these effects have been attributed to Wnt pathway action on the cell cycle. Researchers at UCI and UCLA decided to investigate whether Wnt had another unsuspected role in cancer, specifically in regulating energy metabolism, due to their observation of changes in the expression of metabolic enzymes in colon cancer cells. Their findings implicate Wnt signaling in energy metabolism in colon cancer and suggest the possible development of cancer therapies that target the Wnt signaling pathway.
October 03, 2013 High School Students React to Visit from UCLA Researcher on Stem Cell Awareness Day Los Angeles/California Institute For Regenerative Medicine – Dr. Michael Teitell presented three seminars to High School students on the importance of stem cell research on October 2, 2013, marking the sixth annual Stem Cell Awareness Day. Efforts such as his and other scientists, to educate students with the intent to enter college some day, have left many inspired and considering studying stem cell research.
August 21, 2013 Gerecht Lab Provides New & Notable Commentary on Biophysical Journal Paper from Teitell Lab Biophysical Journal – With the use of live cell interferometry (LCI), a non-invasive microscopy technique, researchers at UCLA have measured the biomass and locomotion of human-induced pluripotent stem cells (hPSCs). This novel approach has allowed scientists to follow the physical changes in hPSCs through growth, differentiation, and even apoptosis.
April 17, 2013 Small Molecule May Inhibit Malignancies in Stem Cell-Derived Therapies Los Angeles/Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research and Jonsson Comprehensive Cancer Center – Scientists at UCLA have identified MitoBloCK-6 as a small molecule that may prevent unintended cells from developing into malignancies during stem cell therapies.
October 25, 2012 Teitell Visits with High School Students and Speaks About Stem Cell Research Los Angeles/California Institute For Regenerative Medicine – In an effort to broaden the scope of college-bound high school students, Dr. Michael Teitell visits with potential next generation scientists and speaks to them about stem cell research, molecular biology, and college admissions.
April 27, 2012 UCLA and CSUN Collaborate in an Effort to Bring New Opportunities to Stem Cell Research Los Angeles/Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research – In a program that bridges the two schools, students from the California State University, Northridge (CSUN) are earning a chance to work in the field of stem cell biology. This California Institute for Regenerative Medicine (CIRM) funded program allows students to participate in research at a University of California, an opportunity that would not be possible at a state university.
March 03, 2012 UCLA Researchers use RNA Import to Compensate for Mutations in Human Mitochondrial DNA Los Angeles/Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research – Researchers have discovered an approach that compensates for deleterious mutations in human mitochodrial DNA through targeted RNA import.
November 15, 2011 Scientists Uncover Mechanism that Regulates Human Pluripotent Stem Cell Metabolism and Cellular Differentiation Los Angeles/Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research – UCLA Researchers have discovered a novel mechanism in pluripotent stem cell metabolism that switches energy production from glycolysis to oxidative phosphorylation during stem cell differentiation.
October 01, 2011 Photothermal Nanoblade Named One of Top Ten Technological Breakthroughs of 2011 Journal of Laboratory Automation – The JALA Editorial Board has selected the photothermal nanoblade as a top ten innovation of 2011, an honor earned through the work and progress in the field of biology and medicine.
September 03, 2011 Nature Photonics Comments on Subcellular Sensing Collaborative Study from Zhang and Teitell Labs Nature Photonics – Researchers create an innovative method for mapping extracellular signalling at the molecular level. Using nanoimprint lithography and Jurkat T cells (a type of cell used in cancer research), they illustrated the pathway that cytokine molecules take when secreted during intercellular communication.
July 29, 2011 Photothermal Nanoblade featured on podcast, “This Week in Microbiology” MicrobeWorld – Microbiology podcast hosts discuss the photothermal nanoblade as a new tool for the delivery of large cargo, enabling the dissection of intracellular pathogen lifecycles.
June 09, 2011 Roche to provide UCLA Researchers with Access to Cutting Edge Technology Roche and UCLA have reached an agreement that will provide the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA and UCLA’s Jonsson Comprehensive Cancer Center with access to the latest in genomic technologies from Roche’s research and development pipeline.
January 27, 2011 UCLA Researchers Develop New Tool for Efficient Large Cargo Delivery Into Mammalian Cells Chemical and Engineering News – Researchers have developed a photothermal nanoblade that cuts a resealable, micrometer-sized hole in the cell membrane, enabling efficient delivery of large cargos.
January 05, 2011 California NanoSystems Institue (CNSI) 2010 Report highlights the Teitell lab Los Angeles/California NanoSystems Institute – Through a groundbreaking ABRAXIS/CNSI collaboration the Teitell lab is developing an interference based microscope to measure cell motion and growth. These measurements can be applied to live tumor cells undergoing drug treament to enable development of personalized drug therapies. (pg 11) Teitell publications on an important signaling pathway in B-cell development and a protein that imports RNA into the mitochondria are featured. (pg 13)
October 21, 2010 Teitell discusses DNA Methylation and Gene Regulation on Science Webinar: The Epigenetics Challenge Science AAAS – Epigenetics is being recognized as an increasingly important area of research that involves an understanding of the molecular mechanisms that influence the phenotypic outcome of the genome without alteration of the DNA sequence.
September 23, 2010 Researchers Discover New Signaling Pathway that Controls Cell Development and Cancer Los Angeles/Johnson Comprehensive Cancer Center – Researchers at UCLA’s Jonsson Comprehensive Cancer Center have discovered a new cell signaling pathway that controls cell growth and development, a pathway that when defective helps promote the formation of several major forms of human cancer including lymphoma and leukemia.
August 06, 2010 Researchers Discover Protein that Shuttles RNA into Cell Mitochondria Los Angeles/Johnson Comprehensive Cancer Center – Researchers at UCLA’s Jonsson Comprehensive Cancer Center and the departments of Chemistry and Biochemistry and Pathology and Laboratory Medicine have uncovered a role for an essential cell protein in shuttling RNA into mitochondria, the energy-producing “power plant” of the cell.
July 22, 2010 Valley Papers Explore Stem Cell Research for College Students The San Fernando Valley Sun and San Fernando Business Journal reported on a program that pairs Cal State University Northridge students with researchers from the UCLA Broad Stem Cell Research Center.
July 06, 2010 Teitell Comments on California Institute for Regenerative Medicine (CIRM) CSUN-UCLA BRIDGES Stem Cell Training Grant Program Northridge Magazine, CSUN, UCLA Pair Up to Prepare Stem Cell Researchers: Damaged hearts regenerate. Paralyzed children run again. The blind regain vision, and cancer is eradicated.
June 23, 2010 Teitell provides Perspective on “Nuclear Role of WASp in the Pathogenesis of Dysregulated Th1-Immunity in Human Wiskott-Aldrich Syndrome in Science Translational Medicine Alternative Control What’s WASp Doing in the Nucleus? Wiskott-Aldrich syndrome (WAS) is a rare X-linked recessive immunodeficiency disorder of childhood that is caused by mutations in the WAS gene.
October 10, 2009 B-Cell Lymphoma Protected By SPAK Silencing ScienceDaily, Oct. 10, 2009 — A group led by Dr. Michael Teitell at UCLA has demonstrated that misregulation of the protein SPAK may contribute to B-cell lymphoma development.
August 21, 2009 Teitell lab receives $1.32M from CIRM Basic Biology Award San Francisco, Calif., August 20, 2009 –- A $16 million infusion from the California Institute for Regenerative Medicine, the state stem cell agency
March 26, 2009 Teitell comments on ‘Noncoding DNA copy number variation links to gene expression in stem cells’ in Nature Reports Stem Cells Mariano Loza Coll, March 2009 / Nature Reports Stem Cells — A genome-wide study reveals an association between CNVs and gene activity in haematopoietic stem cells.
November 26, 2008 Teitell comments on ‘From One, many genetically different embryonic stem cells’ in Nature Reports Stem Cells Monya Baker, November 2008 / Nature Reports Stem Cells — Copy number variants crop up in routine ES cell culture.
August 04, 2008 NLLS Honors Five Scientists for Outstanding Work in Blood Cancer Research Andrea Greif, White Plaines, NY, August 2008 / The Leukemia & Lymphoma Society — The Leukemia & Lymphoma Society (LLS) has named five researchers as Stohlman Scholars, recognizing their outstanding contributions to the advancement of blood cancer research. The honors will be officially announced at the LLS Stohlman Scholar Scientific Symposium, Nov. 6-7, in Kansas City, MO.
July 10, 2008 Nature Reports Stem Cells; How to assess a stem cell genome Nature Reports Stem Cells — As potential therapies derived from pluripotent stem-cell lines move towards the clinic, researchers have yet to address an essential, practical question: how should cells be screened for genetic variants that contribute to cancer or other diseases? The tools to address this question exist, but discussions on how to use them for this purpose are rare and uncoordinated.
June 27, 2008 Teitell Lab Featured on JOVE (Journal of Visualized Experiments); Watch Online Probing for Mitochondrial Complex Activity in Human Embryonic Stem Cells Watch In this video, we will show you how the mitochondrial respiratory chain complexes of human embryonic stem cells can be analyzed using in gel activity assays.
June 19, 2008 Teitell comment on ChIP-seq ES cell pluripotency study in Nature Reports Stem Cells Monya Baker, June 2008 / Nature Reports Stem Cells — An analysis of transcription factor binding sites finds clusters that clarify cooperative binding.
June 13, 2008 Nature Photonics Research Highlights: FEOET from Chiou and Teitell lab Applied Physics Letters publication June 2008, Vol. 2, pg. 331/ Nature Photonics — Scientists based in the USA and Austria report a new type of optoelectronic tweezers that uses floating electrodes. Their tweezers can drive the movement of water drops through an immersion of oil.
June 04, 2008 Scientists Win $2.25 Million Grant to Fund Research into Prostate Cancer Stem Cells Los Angeles, CA, June 2008 / Jonsson Comprehensive Cancer Center — A team of researchers from UCLA’s Jonsson Cancer Center and the Broad Stem Cell Research Center has received a $2.25 million grant to study prostate cancer stem cells and better define the role they play in cancer development, drug resistance and disease recurrence.
April 10, 2008 Some human embryonic stem cells have more gene copies than others Lindsay Borthwick, April 2008 / Nature Reports Stem Cells — In the past few years, with the development of new tools for examining the human genome, researchers have found large segments of DNA that are copied or deleted in different individuals so that some people have more than two copies, only one copy or no copies of certain genes.
March 27, 2008 UCLA Researchers examine Human Embryonic Stem Cell Genome 2008 / EurekAlert! Public News List — Stem cell researchers from UCLA used a high resolution technique to examine the genome, or total DNA content, of a pair of human embryonic stem cell lines and found that while both lines could form neurons, the lines had differences in the numbers of certain genes that could control such things as individual traits and disease susceptibility.
February 01, 2008 Most-accessed articles in Nanotechnology Philadelphia, PA, February 2008 / Nanotechnology — A collaborative article from the Teitell and Gimzewski Labs, Single molecule transcription profiling with AFM (Reed, J., et. al., Nanotechnology, 2007), is one of the most-accessed articles in the interdisciplinary journal Nanotechnology for the year 2007.
April 12, 2007 Meet the Researcher from eNEWSLINE – Q & A with M. Teitell Los Angeles, CA, April 2007 /eNEWSLINE/Peter — Dr. Teitell, can you tell us about your work? We’re using a powerful technique called restriction landmark genomic scanning to investigate the causes of NHL. Research by Dr. Mike Teitell identifying genes that when inactivated help cause B-cell non-Hodgkin’s lymphoma (NHL) was featured in the March 4 issues of the trade publications Cancer Weekly, Oncology Business Week, Lab Business Week, Cancer Law Weekly, Genetics & Environmental Law Weekly, Law & Health Weekly, Biotech Law Weekly, Drug Week, Genomics & Genetics Weekly, Health Business Week, Biotech Week, Genetics & Environmental Health Week, Clinical Oncology Week, Proteomics Weekly, Hematology Week, Health & Medicine Week, Biotech Business Week, World Disease Weekly, Science Letter, Life Science Weekly and Drug Law Weekly. Teitell is an associate professor of pediatrics and pathology and laboratory medicine and a researcher at UCLA’s Jonsson Cancer Center. Go Back
February 23, 2007 Scientists get funding to investigate how stem cells function Los Angeles, CA, Feb. 23 /UCLA Today Online/ — The Proposition 71 bond measure that California voters approved more than two years ago to fund human embryonic stem cell research is finally making its first pay-off: UCLA scientists will receive more than $4 million over two years.
February 21, 2007 UCLA receives stem cell grants Los Angeles, CA, Feb. 21 /Dailybruin/ — UCLA researchers received grants totalling close to $4.2 million to investigate issues concerning human embryonic stem cells for the next two years. Research by Dr. Mike Teitell identifying genes that when inactivated help cause B-cell non-Hodgkin’s lymphoma (NHL) was featured Jan. 30 in Yahoo! News, KTBS-TV (LA), Genetic Engineering News, PR News Wire, Medical News Today,, and The story appeared Feb. 2 in and in Bio-IT World. Teitell is an associate professor of pediatrics and pathology and laboratory medicine and a researcher at UCLA’s Jonsson Cancer Center.
February 20, 2007 California Awards First Stem Cell Research Grants; UCLA Scientists Garner 7 of 72 Grants Given UCLA News — UCLA scientists have received seven of 72 seed grants awarded by the state to fund stem cell research, the first money distributed for work on human embryonic stem cells since California voters approved Proposition 71 in November 2004. Seed grant funding totaled $45 million.
February 16, 2007 $45 Million Headed for Stem Cell Research in California Genetic Engineering & biotechnology News/Business Wire — More than two years after voters approved a $3 billion program to fund stem cell research in California, the state has approved the first grants focused solely on human embryonic stem cell research.
January 20, 2007 UCLA Researchers Discover Genes Linked to Lymphoma, Opening Way for New Targeted Drugs January 20, 2007 WHITE PLAINS, N.Y., Jan. 30 /PRNewswire/ — Lymphoma is a blood cancer that affects more than 60,000 Americans each year. Researchers at The University of California Los Angeles have identified genes that when inactivated help cause B-cell non-Hodgkin’s lymphoma (NHL).